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P?Rectangle 44 p p ܏ݍy\O(u  G  *  P.?Rectangle 45"PK![Content_Types].xml|N0 HC+jS8 @:Q۸ ??\o<7p]V޷O(I'6E=, ){Ō4>I)q7UuDހǏ)}nL"Mᴸ&g0eSA)΄2';2 WYu7{ɯΒzŘqFrj9K*(]mOlPK!Z,[ _rels/.relslj0 ``t_Pƈ[>,dgzjǎ?I'f#®Pb-\/Ƿ0Z]nLnp__3.iJV KQBiDžrL,Vʌ/7р4`ANar+m;E/'3U Aںv83/PK!KGdrs/downrev.xmlDj1!\R3†QD*ZPc:N!IǙo.z- ,F1Y0jLٛ9SEJC2}QF?ؕi 1+-'ɂklL|mMw%<]wɱ;Suy}Vyhq)ƣ$,Exu:$DU~PK-![Content_Types].xmlPK-!Z,[ _rels/.relsPK-!KGdrs/downrev.xmlPK % ,$   eRl paracrine        V.?Rectangle 46"PK![Content_Types].xml|N0 HC+jS8 @:Q۸ ??\o<7p]V޷O(I'6E=, ){Ō4>I)q7UuDހǏ)}nL"Mᴸ&g0eSA)΄2';2 WYu7{ɯΒzŘqFrj9K*(]mOlPK!Z,[ _rels/.relslj0 ``t_Pƈ[>,dgzjǎ?I'f#®Pb-\/Ƿ0Z]nLnp__3.iJV KQBiDžrL,Vʌ/7р4`ANar+m;E/'3U Aںv83/PK!Udrs/downrev.xmlDQO0M5HbHpe]\6>9Nr;5& 02i?׏90H!#yX.noXH{1[:B"s_+''uC%u$r {Z)w'- ;QeQk~ q7 4G6oEUR4͟ء\+9Q0FUPK-![Content_Types].xmlPK-!Z,[ _rels/.relsPK-!Udrs/downrev.xmlPK,$  `" G u    C *Group 47#"PK![Content_Types].xml|N0 HC+jS8 @:Q۸ ??\o<7p]V޷O(I'6E=, ){Ō4>I)q7UuDހǏ)}nL"Mᴸ&g0eSA)΄2';2 WYu7{ɯΒzŘqFrj9K*(]mOlPK!Z,[ _rels/.relslj0 ``t_Pƈ[>,dgzjǎ?I'f#®Pb-\/Ƿ0Z]nLnp__3.iJV KQBiDžrL,Vʌ/7р4`ANar+m;E/'3U Aںv83/PK!qgdrs/downrev.xmlDOMk@5(-]C+=HFoCvLِ&w >gM bĥ W [ˤAi#p!RTP{ߥR&.qn7+{Ci"ߤCCj*o0/pvky9&| I)q7UuDހǏ)}nL"Mᴸ&g0eSA)΄2';2 WYu7{ɯΒzŘqFrj9K*(]mOlPK!Z,[ _rels/.relslj0 ``t_Pƈ[>,dgzjǎ?I'f#®Pb-\/Ƿ0Z]nLnp__3.iJV KQBiDžrL,Vʌ/7р4`ANar+m;E/'3U Aںv83/PK!\mdrs/downrev.xmlDOKk@M*-% VzB ކ!BNGӈ:W[V/"ą5 ~N/ GX&9H75&Mї"KPA}H銊 mwA`WJM#_]94TҶvlvNǤ|V <_aPK-![Content_Types].xmlPK-!Z,[ _rels/.relsPK-!\mdrs/downrev.xmlPK ,$D  00 C *Group 53"G  2 $  ?Ag ?v~Oval 54v~"@`00 6  .2 % C dg ?Oval 55" 'y ` `" G ( ?  C *Group 56"v B ' 2  ^Ɏ?Oval 57A u 6  2  ^= ?Oval 58= t  6  2  ^ ǎ?Oval 59= [t  6  2  ^Ǝ?Oval 60X  ( 6  2   ^= ?Oval 61 = ( 6  2 ! ^ ?Oval 62  6  2 " ^@?Oval 63? s 6  2 # ^`?Oval 64! YX  6    # J@ABOC`TDEVFQRUVWX ? A#BO6A#BO6`T @ @ `O`TArc 65 '   v u %   C *Group 66#"PK![Content_Types].xml|N0 HC+jS8 @:Q۸ ??\o<7p]V޷O(I'6E=, ){Ō4>I)q7UuDހǏ)}nL"Mᴸ&g0eSA)΄2';2 WYu7{ɯΒzŘqFrj9K*(]mOlPK!Z,[ _rels/.relslj0 ``t_Pƈ[>,dgzjǎ?I'f#®Pb-\/Ƿ0Z]nLnp__3.iJV KQBiDžrL,Vʌ/7р4`ANar+m;E/'3U Aںv83/PK! drs/downrev.xmlDOMk@ DF$)Jo;Q;+VͿ }.M'F\kYA@WV\+:^@8L ?,vj;"KQA}J骆 wAPK=M'([ thFS|6ELJ=.| ?PK-![Content_Types].xmlPK-!Z,[ _rels/.relsPK-! drs/downrev.xmlPK m ,$D  u %  C *Group 67"u %   J@.?Rectangle 68& %  t\O(uNk~ހ  G    # J@ABOC`TDEVFQRUVWX ? A#BO6A#BO6`T @ @ `O`TArc 69u Z d '  00 C *Group 70"  2   ͎?Ag ?v~Oval 71v~"@`00 6  .2  C ώdg ?Oval 72" 'y ` `" G H u  C *Group 73"u 2  ^3ȝ`.?Oval 74u  6     7@AB`TC՛DEF QRUVWX fjJ?.`T%`T`T`TgqtEd,ԛ.`T%`T`T`TgqtEd,ԛ`T @  @  ``T՛Arc 75    P@.?Rectangle 76t  ~~ހVP[\O(uvqQ Tyrp"  g    J  P`.?Rectangle 77"@ 230\O(ue_ action manners 8     tB  Lo?Line 78<qA< 337*/*___PPT10*.td+lMD)' = @B D(' = @BA?%,( < +O%,( < +D' = @B%(D' = @B%(D9' =4@BBBB%(D' =1:Bvisible*o3>+B#style.visibility<*%(D' =-u6Bdiamond(in)*<3<*D' = @B%(D' = @B%(DK' =4@BBB B%(D' =1:Bvisible*o3>+B#style.visibility<*%(D' =-6B+checkerboard(across)*<3<*D' = @B%(D' = @B%(D9' =4@BBBB%(D' =1:Bvisible*o3>+B#style.visibility<* %(D' =-u6Bdiamond(in)*<3<* Dy' = @B%(D' = @B%(D' =A@BBBB0B%(D' =1:Bvisible*o3>+B#style.visibility<*%(D' =+4 8?RCBBCB#ppt_wB*Y3>B ppt_w<*D' =+4 8?RCBBCB#ppt_hB*Y3>B ppt_h<*D' = @B%(D#' = @B%(D' =4@BBBB%(D' =1:Bvisible*o3>+B#style.visibility<* %(D' =+4 8?dCB0-#ppt_w/2BCB#ppt_xB*Y3>B ppt_x<* D' =+4 8?\CB#ppt_yBCB#ppt_yB*Y3>B ppt_y<* D' = @B%(D' = @B%(D;' =4@BBB B%(D' =1:Bvisible*o3>+B#style.visibility<* %(D' =-w6Bdiamond(out)*<3<* DF' = @B%(D' = @B%(D|' =K@BBB%BPB0B%(/%(%D' =1:Bvisible*o3>+B#style.visibility<* %(D' =-6B%barn(outVertical)*<3<* D ' = @B%(D' = @B%(DV' =A@BBB*B0B%(D' =1:Bvisible*o3>+B#style.visibility<*%(D' =-6B)barn(outHorizontal)*<3<*D' = @B%(D#' = @B%(D' =4@BBBB%(D' =1:Bvisible*o3>+B#style.visibility<*%(D' =+4 8?dCB0-#ppt_w/2BCB#ppt_xB*Y3>B ppt_x<*D' =+4 8?\CB#ppt_yBCB#ppt_yB*Y3>B ppt_y<*D' = @B%(D#' = @B%(D' =4@BBBB%(D' =1:Bvisible*o3>+B#style.visibility<*%(D' =+4 8?\CB#ppt_xBCB#ppt_xB*Y3>B ppt_x<*D' =+4 8?dCB1+#ppt_h/2BCB#ppt_yB*Y3>B ppt_y<*D' = @B%(D' = @B%(DD' =A@BBBB0B%(D' =1:Bvisible*o3>+B#style.visibility<*%(D' =-s6Bwipe(left)*<3<*++0+ ++0+ ++0+ ++0+  +"   @Δ(    Ne?Rectangle 2"PK![Content_Types].xml|N0 HC+jS8 @:Q۸ ??\o<7p]V޷O(I'6E=, ){Ō4>I)q7UuDހǏ)}nL"Mᴸ&g0eSA)΄2';2 WYu7{ɯΒzŘqFrj9K*(]mOlPK!Z,[ _rels/.relslj0 ``t_Pƈ[>,dgzjǎ?I'f#®Pb-\/Ƿ0Z]nLnp__3.iJV KQBiDžrL,Vʌ/7р4`ANar+m;E/'3U Aںv83/PK!drs/downrev.xmlDn0D֭,RTTjP |%$ic;Vr43:e֑uƣZΧ%6F;9X.JsGr_.Emʹ+*RF% }-U(JZ [ZUT|Jlu7ߍj<3`z?zWR@O_uwZy` ?PK-![Content_Types].xmlPK-!Z,[ _rels/.relsPK-!drs/downrev.xmlPK` ,$  hIL-4 2   @  Hf?Rectangle 3j  * 40YHe'` Pleiotropy . &8        Ng?Rectangle 4t  ~~ހVP[\O(uvqQ Tyrp"  g    rB  Jo?Line 5<<Œu - C (Group 6#"PK![Content_Types].xml|N0 HC+jS8 @:Q۸ ??\o<7p]V޷O(I'6E=, ){Ō4>I)q7UuDހǏ)}nL"Mᴸ&g0eSA)΄2';2 WYu7{ɯΒzŘqFrj9K*(]mOlPK!Z,[ _rels/.relslj0 ``t_Pƈ[>,dgzjǎ?I'f#®Pb-\/Ƿ0Z]nLnp__3.iJV KQBiDžrL,Vʌ/7р4`ANar+m;E/'3U Aںv83/PK!0\drs/downrev.xmlDOk@ouDĊP#Lٷ!͟o-zf76M#z\mYA@V\*?pYccL ͞h;'g_a6tKn;>Ȯ!M#WQ* *li_Q8lqO5I|6 i+nPK-![Content_Types].xmlPK-!Z,[ _rels/.relsPK-!0\drs/downrev.xmlPK-,$D.~   C (Group 7"-7~ -bk  C (Group 8"Z ~ E  wC (Group 9"z bp  zC *Group 10" _~2   `Ò?Ag ?v~Oval 11v~"@` 6  *2  C Ēdg ?Oval 12" @` \ C 8  {C *Group 13"N G B  Xo?Line 14B  Xo?Line 15B B Xo?Line 168  |C *Group 17"( : B  Xo?Line 18B  Xo?Line 19B B Xo?Line 208  }C *Group 21"  zB  Xo?Line 22B  Xo?Line 23B B Xo?Line 248  ~C *v(Group 25"c  B  Xo?Line 26B  Xo?Line 27B B Xo?Line 288  CC *v(Group 29"  B  Xo?Line 30B  Xo?Line 31B B Xo?Line 328  C *Group 33"E Q B  Xo?Line 34B  Xo?Line 35B B Xo?Line 368  C *vGroup 37"z 1 B  Xo?Line 38B  Xo?Line 39B B Xo?Line 408  CC *vGroup 41" = eB  Xo?Line 42B  Xo?Line 43B B Xo?Line 448  C *ZGroup 45" CB  Xo?Line 46B  Xo?Line 47B B Xo?Line 488  C *vGroup 49" ]WB  Xo?Line 50B  Xo?Line 51B B Xo?Line 528  CC *DGroup 53" !B  Xo?Line 54B  Xo?Line 55B B Xo?Line 56  J?Rectangle 57` 4  cB C  B x ^g ?Line 58- k  y J`?Rectangle 59S (Activation proliferation differentiation) ))  a  J  C *Group 60" B  ^g ?Line 61 h` z  J C *Group 62"z  J  NW.?Text Box 63z J o Mast cell ( 2    ]   C *Group 64"  "  3 BU ?G0*Ag ?v~AutoShape 65v~"@`  6  2  C dg ?Oval 66" > 3  6   d C *Group 67"g 1 z 2 o F<g ?Oval 68d 6  2 p  v<Sdg ?Oval 69" q 6  2 q  v<Sdg ?Oval 70"  6  2 r  vLSdg ?Oval 71"  6  2 s  vSdg ?Oval 72" ky 6  2 t  vSdg ?Oval 73" gu 6  2 u  vSdg ?Oval 74" y 6  2 v  v Sdg ?Oval 75" u 6   bI{ C *Group 76" [ + 2 g F<g ?Oval 77bI{ 6  2 h  v<Sdg ?Oval 78" oL}[ 6  2 i  v<Sdg ?Oval 79" }P^ 6  2 j  v <Sdg ?Oval 80" ^l 6  2 k  v@<Sdg ?Oval 81" iewt 6  2 l  v`<Sdg ?Oval 82" eWse 6  2 m  v<Sdg ?Oval 83" wiw 6  2 n  v<Sdg ?Oval 84" s[i 6    C *Group 85" ? 2 _ F <g ?Oval 86 6  2 `  v <Sdg ?Oval 87"  6  2 a  v <Sdg ?Oval 88"  6  2 b  v <Sdg ?Oval 89"  6  2 c  v<Sdg ?Oval 90"  6  2 d  v`<Sdg ?Oval 91"  6  2 e  v<Sdg ?Oval 92"  6  2 f  v<Sdg ?Oval 93"  6  2  C `0Sdg ?Oval 94"   )  6  2  C 1Sdg ?Oval 95" m  6  2  C 2Sdg ?Oval 96"   6  2  C 3Sdg ?Oval 97" 9 N  6  2   C 4Sdg ?Oval 98"  '  6  2 ! C 6Sdg ?Oval 99"    6  2 " C  7Sdg ?Oval 100" w $  6  2 # C @8Sdg ?Oval 101" 1 G H a  6  2 $ C `9Sdg ?Oval 102" {   6  2 % C :Sdg ?Oval 103" {  6  2 & C ;Sdg ?Oval 104" e c { {  6  2 ' C <Sdg ?Oval 105"   6  2 ( C =Sdg ?Oval 106"   6  2 ) C ?Sdg ?Oval 107" g {  6  2 * C `@Sdg ?Oval 108"  " / :  6  2 + C ASdg ?Oval 109" > R   6  2 , C BSdg ?Oval 110" 9 N &  6  2 - C CSdg ?Oval 111" ) @  6  2 . C DSdg ?Oval 112"   6  2 / C FSdg ?Oval 113" J _  6  2 0 C A Sdg ?Oval 114"      6  2 1 C GSdg ?Oval 115" 1 O J h  6  2 2 C HSdg ?Oval 116"  a  z  6  2 3 C ISdg ?Oval 117"  e ! }  6  2 4 C JSdg ?Oval 118"   +  6  2 5 C LSdg ?Oval 119" ~  +  6  2 6 C  MSdg ?Oval 120" i Y ~ p  6  , d 7C ,Group 121" ' 2 W H <g ?Oval 122d 6  2 X  x@<Sdg ?Oval 123" q 6  2 Y  x`<Sdg ?Oval 124"  6  2 Z  x<Sdg ?Oval 125"  6  2 [  x<Sdg ?Oval 126" ky 6  2 \  x<Sdg ?Oval 127" gu 6  2 ]  x@<Sdg ?Oval 128" y 6  2 ^  x` <Sdg ?Oval 129" u 6  , d 8C ,Group 130"9 \ 2 O Hg ?Oval 131d 6  2 P  xSdg ?Oval 132" q 6  2 Q  x Sdg ?Oval 133"  6  2 R  x@Sdg ?Oval 134"  6  2 S  x`Sdg ?Oval 135" ky 6  2 T  xSdg ?Oval 136" gu 6  2 U  xSdg ?Oval 137" y 6  2 V  x<Sdg ?Oval 138" u 6  , d 9C ,Group 139" < c 2 G H@Lg ?Oval 140d 6  2 H  xSdg ?Oval 141" q 6  2 I  x Sdg ?Oval 142"  6  2 J  x@Sdg ?Oval 143"  6  2 K  x`Sdg ?Oval 144" ky 6  2 L  xSdg ?Oval 145" gu 6  2 M  xSdg ?Oval 146" y 6  2 N  xSdg ?Oval 147" u 6  2 : C `OSdg ?Oval 148"    6  2 ; C LSdg ?Oval 149" ] m  6  2 < C LSdg ?Oval 150"   6  2 = C LSdg ?Oval 151"   6  2 > C  LSdg ?Oval 152" s  6  2 ? C @LSdg ?Oval 153"   6  2 @ C `LSdg ?Oval 154" ; N  6  2 A C LSdg ?Oval 155"   6  2 B C LSdg ?Oval 156"   6  2 C C LSdg ?Oval 157"   6  2 D C LSdg ?Oval 158"    6  2 E C LSdg ?Oval 159"   6  2 F C  LSdg ?Oval 160" J \  6    R`Y.?Rectangle 161&* e  o proliferation    0i   C ,Group 162"0i    R m?Rectangle 163 `   o Thymus cell 2    B   `g ?Line 164  RZ.?Rectangle 165%i` Z   @  C ,Group 166"e 0 C 2   r\.sssdg ?Oval 167" @  6  ,2  C  ].vvdg ?Oval 168" m \ C   Rj?Rectangle 169"@   o proliferation    33___PPT10+I+ D3' = @B D' = @BA?%,( < +O%,( < +D' = @B%(D' = @B%(D>' =A@BBBB0B%(D' =1:Bvisible*o3>+B#style.visibility<*%(D' =-m6Bbox(in)*<3<*D' = @B%(D' = @B%(DK' =4@BBB B%(D' =1:Bvisible*o3>+B#style.visibility<*%(D' =-6B+checkerboard(across)*<3<*+8+0+ +"   rrP r(   Z  FT.?Text Box 2"PK![Content_Types].xml|N0 HC+jS8 @:Q۸ ??\o<7p]V޷O(I'6E=, ){Ō4>I)q7UuDހǏ)}nL"Mᴸ&g0eSA)΄2';2 WYu7{ɯΒzŘqFrj9K*(]mOlPK!Z,[ _rels/.relslj0 ``t_Pƈ[>,dgzjǎ?I'f#®Pb-\/Ƿ0Z]nLnp__3.iJV KQBiDžrL,Vʌ/7р4`ANar+m;E/'3U Aںv83/PK!drs/downrev.xmlDJ1E&*elZDP(S7$}vys9`;vwG+Z ۟χ1)# '0LT*:lR2%XkG')rOBܢqAcOJXuR/k55B,\ X!]ǩ+o%xX8QDAB̺Y PK-![Content_Types].xmlPK-!Z,[ _rels/.relsPK-!drs/downrev.xmlPK   ,$ ( 7.bb'`Antagonism 0 2&8      <  H`.?Rectangle 3,\ s & 5.͑S'`Redundancy . &8      B  H@?Rectangle 4"PK![Content_Types].xml|N0 HC+jS8 @:Q۸ ??\o<7p]V޷O(I'6E=, ){Ō4>I)q7UuDހǏ)}nL"Mᴸ&g0eSA)΄2';2 WYu7{ɯΒzŘqFrj9K*(]mOlPK!Z,[ _rels/.relslj0 ``t_Pƈ[>,dgzjǎ?I'f#®Pb-\/Ƿ0Z]nLnp__3.iJV KQBiDžrL,Vʌ/7р4`ANar+m;E/'3U Aںv83/PK!51drs/downrev.xmlDAK1!&b[֦PhWfq,Ilo {bNCfflFun,D gI…W ;-vcbCtcyh5 7y19 !`osƑ4_o#aV04TRޤ#H)?7u(_ԋ0-l˧C$/! fݬ |PK-![Content_Types].xmlPK-!Z,[ _rels/.relsPK-!51drs/downrev.xmlPK ,$  6. 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