姓 名：李晓波
职 称：副教授
电 话：021-54237612
电子邮箱：xbli@fudan.edu.cn
办公地点：上海市徐汇区东安路130号西7号楼208
教育经历：
1997.09—2002.07，山西医科大学临床医学专业本科生
2002.09—2007.07，williamhill官网病理学与病理生理学专业博士研究生2005.07—2007.05，美国弗吉尼亚联邦大学胃肠病学系联合培养
工作经历：
2007.07—2013.12，williamhill官网生理与病理生理学系讲师
2013.06—2014.06，哈佛大学公共卫生学院基因与复杂病学系访问学者2014.01—至今，williamhill官网生理与病理生理学系副教授
获得奖项：
2020，上海医学院第三届课程思政教案大赛一等奖
2019，复旦大学上海医学院MBBS项目青年教师英语授课比赛三等奖
2018，复旦大学青年教师教学比赛（医科组）二等奖
研究方向：
1. 脂质代谢与疾病 探讨胆固醇硫酸化修饰在肠道及机体胆固醇代谢平衡及相关疾病中的重要作用及机制
2. 药物性肝损伤
科研项目：
2022，国家自然科学基金面上项目，“胆固醇硫酸酯在溃疡性结肠炎粘膜愈合中的作用和机制研究”，主持
2018，国家自然科学基金委员会面上项目，“羟基类固醇硫酸基转移酶2B1调控肠道脂质吸收的作用及机制研究”，主持
2017，上海市自然科学基金面上项目，“羟基类固醇硫酸基转移酶2B1调控肠上皮细胞乳糜微粒装配合成中的作用及机制研究”，主持
课程讲授：
本科生课程：
研究生课程：
高级病理生理学、人体病理生理学、实用生物医学实验技术
学术兼职：
中国病理生理学会内分泌与代谢专业委员会 青年委员
代表性论著：
1. Zheng Y#, Sun W#, Shan C, Li B, Liu J, Xing H, Xu Q, Cui B, Zhu W, Chen J, Liu L, Yang T*, Sun N*, Li X*. b-Hydroxybutyrate Inhibits Ferroptosis-mediated Pancreatic Damage in Acute Liver Failure through the Increase of H3K9bhb. Cell Rep. 2022 Dec. 20;41(12): 111847.
2. Zheng Y#, Sun W#, Wang Z, Liu J, Shan C, He C, Li B, Hu X, Zhu W, Liu L, Lan F, Jiang C, Zhao C, Li X*, Sun N*. Activation of Pancreatic Acinar FXR Protects against Pancreatitis via Osgin1-Mediated Restoration of Efficient Autophagy. Research (Wash D C). 2022 Nov 2; 2022:9784081.
3. Xu D#, Ma R#, Ju Y, Song X, Niu B, Hong W, Wang R, Yang Q, Zhao Z, Zhang Y, Zheng Y, Bai Q, Lv M, Sun N*, Li X*. Cholesterol sulfate alleviates ulcerative colitis by promoting cholesterol biosynthesis in colonic epithelial cells. Nat Commun. 2022 Jul 30;13(1):4428.
4. Niu B#, Lei X#, Xu Q#, Ju Y, Xu D, Mao L, Li J, Zheng Y, Sun N, Zhang X*, Mao Y*, Li X*. Protecting mitochondria via inhibiting VDAC1 oligomerization alleviates ferroptosis in acetaminophen-induced acute liver injury. Cell Biol Toxicol. 2022 Jun;38(3):505-530.
5. Lei X#, Xu Q#, Li C#, Niu B, Ming Y, Li J, Tang Y, Li X, Tang J, Wu J, Ju Y, Yao L, Wang B, Miao Q, Zhong W, Zhi Y, Xu L, Li C*, Li X*, Mao Y*. Egr1 confers protection against acetaminophen induced hepatotoxicity via transcriptional upregulating of Acaa2. Int J Biol Sci. 2022 May 29;18(9):3800-3817.
6. Hong W#, Xu D#, Song X#, Niu B, Zhuang Z, Lu Y, Lei X, Ma R, Lu C, Sun N, Mao Y*, Li X*. Vitamin A and retinoic acid accelerate the attenuation of intestinal adaptability upon feeding induced by high-fat diet in mice. J Nutr Biochem. 2021 Nov; 97:108803.
7. Zheng Y#, Cui B#, Sun W, Wang S, Huang X, Gao H, Gao F, Cheng Q, Lu L, An Y, Li X*, Sun N*. Potential Crosstalk between Liver and Extra-liver Organs in Mouse Models of Acute Liver Injury. Int J Biol Sci. 2020 Feb 10;16(7):1166-1179.
8. Hong W#, Guo F#, Yang M, Xu D, Zhuang Z, Niu B, Bai Q*, Li X*. Hydroxysteroid sulfotransferase 2B1 affects gastric epithelial function and carcinogenesis induced by a carcinogenic agent. Lipids Health Dis. 2019 Nov 22;18(1):203.
9. Du X#, Xu Q#, Pan D, Xu D, Niu B, Hong W, Zhang R, Li X*, Chen S*. HIC-5 in cancer-associated fibroblasts contributes to esophageal squamous cell carcinoma progression. Cell Death Dis. 2019 Nov 18;10(12):873.
10. Tang Y#, Zhang J#, Li J#, Lei X, Xu D, Wang Y, Li C, Li X*, Mao Y*. Turnover of bile acids in liver, serum and caecal content by high-fat diet feeding affects hepatic steatosis in rats. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Oct;1864(10):1293-1304.
11. Li C#, Ming Y#, Wang Z, Xu Q, Yao L, Xu D, Tang Y, Lei X, Li X*, Mao Y*. GADD45α alleviates acetaminophen-induced hepatotoxicity by promoting AMPK activation. Cell Mol Life Sci. 2019 Jan;76(1):129-145.
12. Li C#, Ming Y#, Hong W, Tang Y, Lei X, Li X*, Mao Y*. Comparison of hepatic transcriptome profiling between acute liver injury and acute liver failure induced by acetaminophen in mice. Toxicol Lett. 2018 Feb; 283:69-76.
13. Wang Z, Yang X, Chen L, Zhi X, Lu H, Ning Y, Yeong J, Chen S, Yin L, Wang X*, Li X*. Upregulation of hydroxysteroid sulfotransferase 2B1b promotes hepatic oval cell proliferation by modulating oxysterol-induced LXR activation in a mouse model of liver injury. Arch Toxicol. 2017 Jan;91(1):271-287.