姓 名：张威 职 称：副教授 电 话：021-54237002 电子邮箱：wzhang@shmu.edu.cn 办公地点：上海市徐汇区东安路131号东1号楼217 教育经历： 1991.09—1996.07 牡丹江医学院临床医学专业本科生 1997.09—2000.07 哈尔滨医科大学生理学专业硕士研究生 工作经历： 2000.07—至今 williamhill官网教师 研究方向： 1. 急性肾损伤的发生机制 2. 急性肾损伤向慢性肾病转化的机制研究 科研项目： 2021，上海市自然科学基金项目，“线粒体抗氧化蛋白酶Prdx3功能异常在蛋白尿引起肾损伤中的作用及机制研究”，主持 2016，上海市教育委员会专项经费项目，“上海市学校卫生工作信息化建设情况及发展规划研究”，主持 2011，国家自然科学基金青年项目，“H2S 抑制内质网应激IRE1 通路激活缓解高糖引起的肾脏系膜细胞功能异常与肾损伤”，主持 2005，上海市卫健委项目，“statin对老年小鼠内皮祖细胞功能的修复作用及其与端粒的关系”，主持 课程讲授： 本科生课程： 生理学 研究生课程： 高级生理学 学术兼职：
代表性论著： 1. Miao N, Yin F, Xie H, Wang Y, Xu Y, Shen Y, Xu D, Yin J, Wang B, Zhou Z, Cheng Q, Chen P, Xue H, Zhou L, Liu J, Wang X*, Zhang W*, Lu L*. The cleavage of gasdermin D by caspase-11 promotes tubular epithelial cell pyroptosis and urinary IL-18 excretion in acute kidney injury. Kidney Int. 2019, 96(5):1105-1120. 2. Xu D#, Chen P#, Wang B, Wang Y, Miao N, Yin F, Cheng Q, Zhou Z, Xie H, Zhou L, Liu J, Wang X, Zent R, Lu L*, Zhang W*. NIX-mediated mitophagy protects against proteinuria-induced tubular cell apoptosis and renal injury. Am J Physiol-Renal Physiol. 2019, 316(2): F382-F395 3. Xu D, Chen PP, Zheng PQ, Yin F, Cheng Q, Zhou ZL, Xie HY, Li JY, Ni JY, Wang YZ, Chen SJ, Zhou L, Wang XX, Liu J, Zhang W*, Lu LM*. KLF4 initiates sustained YAP activation to promote renal fibrosis in mice after ischemia-reperfusion kidney injury. Acta Pharmacol Sin. 2021, 42(3): 436-450. 4. Xie H, Miao N, Xu D, Zhou Z, Ni J, Yin F, Wang Y, Cheng Q, Chen P, Li J, Zheng P, Zhou L, Liu J, Zhang W*, Wang X*, Lu L*. FoxM1 promotes Wnt/β-catenin pathway activation and renal fibrosis via transcriptionally regulating multi-Wnts expressions. J Cell Mol Med. 2021, 25(4): 1958-1971. 5. Xu D#, Wang B#, Chen PP, Wang YZ, Miao NJ, Yin F, Cheng Q, Zhou ZL, Xie HY, Zhou L, Liu J, Wang XX, Xue H*, Zhang W*, Lu LM*. c-Myc promotes tubular cell apoptosis in ischemia-reperfusion-induced renal injury by negatively regulating c-FLIP and enhancing FasL/Fas-mediated apoptosis pathway. Acta Pharmacol Sin. 2019, 40(8): 1058-1066. 6. Shao D, Ni J, Shen Y, Liu J, Zhou L, Xue H, Huang Y, Zhang W*, Lu L*. CHOP mediates XBP1S-induced renal mesangial cell necrosis following high glucose treatment. Eur J Pharmacol. 2015, 5(758): 89-96. 7. Jin-lan XU#, Xin-xin GAN #, Jun NI, De-cui SHAO, Yang SHEN, Nai-jun MIAO, Dan XU, Li ZHOU, Wei ZHANG*, Limin LU*. SND p102 promotes extracellular matrix accumulation and cell proliferation in rat glomerular mesangial cells via the AT1R/ERK/Smad3 pathway. Acta Pharmacol Sin. 2018, 39: 1513–1521. 8. W. Zhang#, X. Wang#, H. Jin, R. Qian, G. Zhang, S. Chen* and R. Hu*. Effects of high glucose plus high insulin on proliferation and apoptosis of mouse endothelial progenitor cells. Inflamm. res. 2008, 57: 571–576. 9. Wei Zhang, Xin-Hong Wang, Si-Feng Chen, Guo-Ping Zhang, Ning Lu, Ren-Ming Hu and Hui-Ming Jin. Biphasic response of endothelial progenitor cell proliferation induced by high glucose and its relationship with reactive oxygen species. Journal of Endocrinology, 2008, 197: 463–470. 10. Wei Zhang, Guoping Zhang, Huiming Jin*, Characteristics of bone marrow-derived endothelial progenitor cells in aged mice. BBRC. 2006, 348: 1018–1023. |
