姓名：陈长瑞
职称：副教授
电话：021-54237380
电子邮箱：changruichen@fudan.edu.cn
办公地点：上海市徐汇区东安路130号7号楼111室
个人主页/课题组网页：
教育经历：
1996.09—2000.09兰州医学院
2000.09—2003.07兰州大学药理系硕士研究生
2004.09—2007.07复旦大学药理系博士研究生
工作经历：
2003.07—2004.09上海中医药大学教师
2007.07—至今williamhill官网药理系教师（2014.07-2015.07美国哈佛大学神经科学系国家公派访问学者）
获得奖项：
2016年获得高等学校科学研究优秀成果奖二等奖
研究方向：
1. 嗜睡症、抑郁焦虑等疾病诱发的睡眠紊乱机制研究
2. 失眠治疗药物开发
科研项目：
1.主持国家自然科学基金青年基金，30901797，莫达非尼觉醒作用部位研究，2010/01-2012/12、20万元、已结题、主持
2.主持国家自然科学基金面上项目，81671317,下丘脑室旁核调控觉醒的神经生物学机制, 2017/01-2020/12、57万元、已结题、主持
课程讲授：
本科生课程：
药理学、功能学试验
研究生课程：定量药理学；高级药理学进展；神经药理学；临床药理学
代表性论著：
1. Wang, Z. #, Zhong, Y.H., #, Jiang, S. #, Qu, W.M. *, Huang, Z.L. * , Chen, C.R. * Case Report: Dysfunction of the Paraventricular Hypothalamic Nucleus Area Induces Hypersomnia in Patients. Front Neurosci. Mar 14;16:830474,2022
2. Zhong ,Y.H. #, Jiang, S. #, Qu, W.M. * , Zhang, W. * , Huang, Z.L. * , Chen, C.R. * Saikosaponin a promotes sleep by decreasing neuronal activities in the lateral hypothalamus. J Sleep Res. Apr;31(2):e13484, 2022.
3. Chen, C.R. *#, Zhong ,Y.H. #, Jiang, S. #, Xu W. #, Xiao L., Wang Z, Qu, W.M. *, Huang, Z.L. * . Dysfunctions of the paraventricular hypothalamic nucleus induce hypersomnia in mice. Elife. Nov 17;10:e69909,2021.
4. Chen, C.R. #, Sun, Y. #, Luo Y.J., Zhou X.Z., Zhao X., Qu, W.M. * , Huang, Z.L. * . Paeoniflorin promotes non-rapid eye movement sleep via A1 receptors. J Pharmacol Exp Ther, Jan;356(1):64-73, 2016.
5. Chen C.Y., Wei X.D.,Chen, C.R. * .3,4,5-trimethoxycinnamic acid, one of the constituents of Polygalae Radix exerts anti-seizure effects via GABAAergic systems in mice, Journal of Pharmacological Sciences. J Pharmacol Sci, Jul 28;S1347-8613(15)00141-3,2015.
6. Chen C.Y., Li W., Qu K.P., CR Chen *. Piperine exerts anti-seizure effects via the TRPV1 receptor in mice. The European Journal of Pharmacology,Aug 15;714(1-3):288-94,2013.
7. CR Chen, SR Yang, YY Liu, WM Qu, Y Urade, ZL Huang*.Roles of adrenergic 1 and dopamine D1 and D2 receptors in the mediation of the desynchronization effects of modafinil in a mouse EEG synchronization model. Plos One, 2013 Oct 7;8(10):e76102.
8. Qu W.M., Yue X.F., Sun Y., Fan K., Chen C.R., Hou Y.P., Urade Y., Huang Z.L *. Honokiol Promotes Non-rapid Eye Movement Sleep via GABAA/benzodiazepine Receptors in Mice.Br J Pharmacol,Oct;167(3):587-98, 2012.
9. Chen, C.R. #, Zhou X.Z. #, Luo Y.J. #, Huang, Z.L. *, Urade, Y. *, Qu, W.M. * . Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, induces sleep via the benzodiazepine site of GABA(A) receptor in mice. Neuropharmacology. Nov;63(6):1191-9, 2012.
10. Chen, C.R. #, Tan,R. #, Qu, W.M. *, Wu,Z., Wang,Y., Urade, Y., Huang, Z.L. * . Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, exerts antiepileptic effects via the GABA/benzodiazepine receptor complex in mice. Br J Pharmacol. Nov; 164(5):1534-46, 2011.