李中华
职 称：青年副研究员
电子邮箱：zhonghua_@fudan.edu.cn
办公地点：上海市徐汇区东安路131号科研二号 楼A4-28
教育经历
工作经历
获得奖项
研究方向
代表性论著
代表性专利
2004.09—2008.06 河南师范大学生物科学专业本科生
2008.09—2013.06 南开大学化学生物学专业博士研究生
2013.07—2015.09 浙江大学博士后
2017.04—2021.2 美国埃默里大学博士后
2021.3—至今 williamhill官网青年副研究员
2013，南开大学优秀毕业生
糖组学领域，利用基于细胞工厂的糖链制备方法和糖芯片技术进行人源糖链库的制备和功能糖组学的研究
糖化学生物学领域，利用酶化学联合方法富集、标记、鉴定并定量疾病相关的糖链修饰
M. R. Kudelka#, Z. Li#, T. A. Chernova, D. F. Smith, X. Song, R. D. Cummings, T. Ju. Cellular O-glycome reporter/amplification (CORA): analytical and preparative tools to study mucin-type O-glycans of living cells. Current Protocols. 2021 Jun;1(6): e142. doi: 10.1002/cpz1.142. (共一)
Z. Li, Q. Zhang, D. Ashline, Y. Zhu, Y. Lasanajak, T. A. Chernova, V. Reinhold, R. D. Cummings, P. G. Wang, T. Ju, D. F. Smith, X. Song. Amplification and Preparation of Cellular O-glycome for Functional O-Glycomics. Analytical Chemistry, 2020, 92(15): 10390-10401.
Q. Zhang#, Z. Li#, T. A. Chernova, V. Saikam, R.D. Cummings, X. Song, T. Ju, D. F. Smith, P. G. Wang. Synthesis and Characterization of Versatile O-glycan Precursors for Cellular O-glycomics. ACS Synthetic Biology. ACS Synthetic Biology. 2019, 11, 2507-2513. (共一)
Z. Li, T. A. Chernova, T. Ju. Novel Technologies for Quantitative O-Glycomics and Amplification/Preparation of Cellular O-Glycans. Synthetic Glycomes. 2019, chap 16, 370-392.
J. Li#, Z. Li#, X. Duan, K. Qin, L. Dang, S. Sun, L. Cai, L. C. Hsieh-Wilson, L. Wu, W. Yi. An Isotope-Coded Photocleavable Probe for Quantitative Profiling of Protein O-GlcNAcylation. ACS Chemical Biology. 2019,14,1,4-10. (共一)
Q. Li#, Z. Li#, X. Duan, W. Yi. A Tandem Enzymatic Approach for Detecting and Imaging Tumor-Associated Thomsen-Friedenreich Antigen Disaccharide. Journal of the American Chemical Society. 2014, 136, 12536-9. (共一)
Z. Li, W. Yi. Regulation of cancer metabolism by O-GlcNAcylation. Glycoconjugate Journal. 2014, 31, 185-91.
Z. Li, T. Li, S. Dai, X. Xie, X. Ma, W. Zhao, W. Zhang, J. Li, P. G. Wang. New Insights into the Pharmacological Chaperone Activity of C2-substituted Glucoimidazoles for the Treatment of Gaucher Disease. Chembiochem. 2013, 14, 1239-1247.
Z. Li, X. Zhang, X. Han, C. Feng, F. Wang, P. G. Wang, J. Shen, Y. Shi. Antitumor effects of a novel histone deacetylase inhibitor NK-HDAC-1 in breast cancer. Oncology Reports. 2013, 30, 499-505.
J. Hou#, Z. Li#, Q. Fang, C. Feng, H. Zhang, W. Guo, H. Wang, G. Gu, Y. Tian, P. Liu, R. Liu, J. Lin, Y. Shi, Z. Yin, J. Shen, P. G. Wang. Discovery and Extensive in Vitro Evaluations of NK-HDAC-1: A Chiral Histone Deacetylase Inhibitor as a Promising Lead. Journal of Medicinal Chemistry. 2012, 55, 3066. (共一)
P. G. wang, J. Shen, Z. Yin, J. Hou, Z. Li, et al. Histone deacetylase inhibitors with branched structure synthesized through click chemistry. WO2011003365
