赵宝玉

  • 职    称:研究员

  • 联系电话:

  • 电子邮箱:baoyuzhao@fudan.edu.cn

  • 办公地点:上海市徐汇区东安路131号复星楼425

  • 教育经历

  • 工作经历

  • 获得人才项目

  • 研究方向

  • 科研项目

  • 代表性论著

  • 2003.09---2007.07     曲阜师范大学生命科学学院        本科

  • 2007.09---2013.07     中国科学院福建物质结构研究所     博士

  • 2013.09---2018.08     美国Texas A&M University        博士后

  • 2018.09---2021.04     美国Texas A&M University        助理研究科学家

  • 2022.02---至今        williamhill官网             研究员

  • 宿主先天免疫应答的分子机制研究。

  • 病原微生物致病以及免疫逃逸的分子机制研究。

  • 基于蛋白质结构的激动剂和抑制剂的研发。

  1. Baoyu Zhao#, Pengbiao Xu#, Chesley M. Rowlett, Tao Jing, Omkar Shinde, Yuanjiu Lei, A. Phillip West, Wenshe Ray Liu* and Pingwei Li*. The Molecular Basis of Tight Nuclear Tethering and Inactivation of cGAS. Nature 587, 673–677 (2020)

  2. Baoyu Zhao#, Fenglei Du#, Pengbiao Xu, Chang Shu, Banumathi Sankaran, Samantha L. Bell, Mengmeng Liu, Yuanjiu Lei, Xinsheng Gao, Xiaofeng Fu, Fanxiu Zhu, Yang Liu, Arthur Laganowsky, Xueyun Zheng, Jun-Yuan Ji, A. Phillip West, Robert O. Watson and Pingwei Li*. A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1. Nature 569, 718–722 (2019)

  3. Baoyu Zhao#, Guanghui Yi#, Fenglei Du#, Yin-Chih Chuang, Robert C. Vaughan, Banumathi Sankaran, C. Cheng Kao* and Pingwei Li*. Structure and function of the Zika virus full-length NS5 protein. Nature Communications 8, 14762 (2017)

  4. Baoyu Zhao#, Chang Shu#, Xinsheng Gao, Banumathi Sankaran, Fenglei Du, Catherine L. Shelton, Andrew B. Herr, Jun-Yuan Ji and Pingwei Li*. Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins. Proc. Natl. Acad. Sci. USA 113 (24), E3403-E3412 (2016)

  5. Baoyu Zhao, Sonu Gandhi, Cai Yuan, Zhipu Luo, Rui Li, Henrik
Gårdsvoll, Valentina de Lorenzi, Nicolai Sidenius, Mingdong Huang* and Michael Ploug*. Stabilizing a flexible interdomain hinge region harboring the SMB binding site drives uPAR into its closed conformation. Journal of Molecular Biology 427 (6 Pt B), 1389-1403 (2015)