米文丽

  • 职    称:副教授

  • 联系电话:021-54237611

  • 电子邮箱:wenlimi@fudan.edu.cn

  • 办公地点:上海市徐汇区东安路130号西13号楼711室

  • 教育经历

  • 工作经历

  • 获得人才项目

  • 获得奖项

  • 研究方向

  • 科研项目

  • 讲授课程

  • 学术兼职

  • 代表性论著

  • 代表性专利

  • 1999.09—2004.06  新乡医学院临床医学专业本科生

  • 2004.09—2009.06  复旦大学上海医学院中西医结合基础专业博士研究生

  • 2009.07—2015.11  williamhill官网讲师

  • 2013.11—2014.11  美国哈佛大学附属麻省总医院麻醉科博士后

  • 2015.12—至今     williamhill官网副教授

  • 2016,尚学计划,williamhill官网

  • 2015,卓学计划,复旦大学

  • 2009,研究学者,复旦大学上海医学院

  • 2018,复旦大学2018年度青年教师教学竞赛(医科组)三等奖

  • 2016,复旦大学第一三共奖教金

  • 2016,中国中西医结合学会科学技术二等奖(第三完成人)

  • 2015,中国神经科学会赛诺菲优秀会议论文奖

  • 疼痛及中药、针刺、运动镇痛的神经生物学机制

  • 瘙痒及中药、针刺止痒的神经生物学机制

  • 2023,国家自然科学基金面上项目,IL-33调控vlPAG星形胶质细胞-GABA能神经元互作介导神经病理性冷痛的作用及机制,主持

  • 2022,科技创新2030—脑科学与类脑研究重大项目,胶质细胞在中枢神经系统稳态和功能维持中的作用,项目骨干

  • 2021,上海市教委高水平地方高校试点建设重点创新团队,针刺治病的神经-内分泌-免疫网络机制,参与

  • 2019,上海市教委高水平地方高校试点建设战略创新团队, 针灸神经免疫网络及调控机理,参与

  • 2018,国家自然科学基金面上项目,冷受体TRPM8在IL-33介导神经病理性冷痛中的作用及机制,主持

  • 2017,上海市卫生和计划生育委员会科研课题青年项目,脊髓NALP1炎症小体在姜黄素缓解小鼠神经痛中的作用及机制,主持

  • 2015,上海市自然科学基金,脊髓IL-33/ST2通路在慢性吗啡镇痛耐受中的作用及信号机制,主持

  • 2011,国家自然科学基金青年项目,脊髓IL-33/ST2通路在大鼠关节炎痛中的作用及细胞分子机制,主持

  • 2011,教育部博士点基金新教师基金项目,脊髓IL-33/ST2通路在电针缓解大鼠关节炎痛中的作用及细胞分子机制,主持

本科生课程:

  • 中西医结合基础概论、疼痛生物医学、走近医学:历史与传承、疼痛:隐藏的慢性杀手、医学生综合素养、中西医学大师与人文素养

研究生课程:

  • 医学研究生学习导引、神经科学原理、中西医结合基础概论、疼痛生物医学、疼痛研究技术与方法、慢性疼痛

  • 2023-今 上海医学会疼痛学专科分会青年委员会副主任委员

  • 2023-今 中国针灸学会针刺麻醉分会委员

  • 2020-今 中国神经科学学会胶质细胞委员会委员

  • 2020-今 中国中西医结合学会科研院所工作委员会委员

  1. Chenghao Wang1, Hui He1, Tianchi Gao, Xinzheng Sun, Lixia Du, Yayue Yang, Jianyu Zhu, Yachen Yang, Yanqing Wang, Wenli Mi*. Analgesic Effect of Exercise on Neuropathic Pain via Regulating the Complement Component 3 of Reactive Astrocytes. Anesthesia & Analgesia. 2024 Jan 31.

  2. Yayue Yang1, Lixia Du1, Jianyu Zhu, Ting Yi, Yachen Yang, Zheng Qiao, Qiliang Maoying, Yuxia Chu, Yanqing Wang, Wenli Mi*. Antipruritic effects of geraniol on acute and chronic itch via modulating spinal GABA/GRPR signaling. Phytomedicine. 2023, 119:154969.

  3. Xinyi Gao1, Yayue Yang1, Jianyu Zhu, Yuxin Zhang, Chenghao Wang, Zhifei Wang*, Wenli Mi*, Lixia Du*. Xanthotoxol relieves itch in mice via suppressing spinal GRP/GRPR signaling. European Journal of Pharmacology. 2023, 960:176147.

  4. Ling Xu1, Ming-Zhe Liu1, Ya-Yue Yang1, Yan Wang, Xiao-Xiao Hua, Li-Xia Du, Jian-Yu Zhu, Yang Shen, Yan-Qing Wang, Ling Zhang, Wen-Li Mi*, Di Mu*. Geraniol enhances inhibitory inputs to the paraventricular thalamic nucleus and induces sedation in mice, Phytomedicine, 2022, 153965.

  5. Xue-Ming Hu1, Wei Yang1, Meng-Ting Zhang1, Li-Xia Du, Jia-He Tian, Jian-Yu Zhu, Yu Chen, Feng Hai, Shen-Bin Liu, Qi-Liang Mao-Ying, Yu-Xia Chu, Hong Zhou, Yan-Qing Wang, Wen-Li Mi*. Glial IL-33 signaling through an ST2-to-CXCL12 pathway in the spinal cord contributes to morphine-induced hyperalgesia and tolerance, Science signaling, 2021, 14(699): eabe3773.

  6. Lixia Du, Xueming Hu, Wei Yang, Hanikezi Yasheng, Shenbin Liu, Wenwen Zhang, Yang Zhou, Wenqiang Cui, Jianyu Zhu, Zheng Qiao, Qiliang Maoying, Yuxia Chu, Hong Zhou, Yanqing Wang, Wenli Mi*. Spinal IL-33/ST2 signaling mediates chronic itch in mice through the astrocytic JAK2-STAT3 cascade. Glia. 2019 67(9):1680-1693.

  7. Lixia Du, Yanqing Wang, Guoqiang Hua, Wenli Mi*. IL-33/ST2 Pathway as a Rational Therapeutic Target for CNS Diseases. Neuroscience 2018 369: 222–230.

  8. Wenli Mi, Shuxing Wang, Zerong You, Grewo Lim, Michael F. McCabe, Hyangin Kim, Lucy Chen, Jianren Mao*. Nortriptyline Enhances Morphine-Conditioned Place Preference in Neuropathic Rats: Role of the Central Noradrenergic System. Anesthesia & Analgesia. 2017 125(3):1032-1041.

  9. Shenbin Liu1, Qian Li1, Mengting Zhang, Qiliang Maoying, Langyue Hu, Gencheng Wu, Wen-Li Mi*, Yanqing Wang*. Curcumin ameliorates neuropathic pain by down-regulating spinal IL-1β via suppressing astroglial NALP1 inflammasome and JAK2-STAT3 signalling. Scientific Reports. 2016;6:28956.

  10. Shenbin Liu1, Wenli Mi1, Qian Li, Mengting Zhang, Ping Han, Shan Hu, Qiliang Maoying, Yanqing Wang*. Spinal IL-33/ST2 signaling contributes to neuropathic pain via neuronal CaMKII-CREB and astroglial JAK2-STAT3 cascades in mice. Anesthesiology, 2015 123(5):1154-1169.

  11. Ping Han1, Shenbin Liu1, Mengting Zhang1, Jing Zhao, Yanqing Wang, Gencheng Wu, Wenli Mi*. Inhibition of spinal Interlukin-33/ST2 signaling and downstream ERK and JNK pathways in electroacupuncture analgesia in formalin mice. PLOS ONE, 0129576, 12, 2015.

  12. Ping Han, Jing Zhao, Shen-Bin Liu, Chang-Jiang Yang, Yan-Qing Wang, Gen-Cheng Wu, Da-Mo Xu, Wen-Li Mi*. Interleukin-33 mediates formalin-induced inflammatory pain in mice. Neuroscience, 2013 241:59-66.

  13. Wen-Li Mi, Qi-Liang Mao-Ying, Xiao-Wei Wang, Xiu Li, Chang-Jiang Yang, Jian-Wei Jiang, Jin Yu, Jun Wang, Qiong Liu, Yan-Qing Wang*, Gen-Cheng Wu. Involvement of spinal neurotrophin-3 in the electroacupuncture analgesia and inhibition of spinal glial activation in rat model of monoarthritis. Journal of Pain. 2011 12(9):974-84.

  1. 一种简易型电动抚触装置 (已授权:ZL202223574272.1)

  2. 一种慢性瘙痒动物模型的制备器 (已授权:ZL201820822114.8)

  3. 抗ST2/IL-1 R4抗体在制备镇痛药物中的用途 (已授权:ZL201210517242.9)

  4. 抗ST2/IL-1 R4抗体在制备防治瘙痒药物中的应用 (已授权:ZL201210517244.8)