高胜蓝
职 称：副研究员
电 话：021-54237656
电子邮箱：sgao @fudan.edu.cn
办公地点：上海市徐汇区东安路131号东一号楼334
教育经历
工作经历
获得人才项目
获得奖项
研究方向
科研项目
讲授课程
代表性论著
2002.09—2006.07 西安交通大学生命科学本科生
2006.09—2008.07 西安交通大学生物化学与分子生物学硕士研究生
2008.08—2013.12 美国密西根州立大学生物化学与分子生物学博士研究生
2014.01—2015.12 美国芝加哥大学医学院博士后
2018.01—2019.01 美国伊利诺伊大学芝加哥分校医学院助理研究员
2019.04—至今 williamhill官网副研究员
2019，上海市浦江人才，上海市科委
2013，美国密西根州立大学博士论文奖，美国密西根州立大学
癌基因/抑癌基因及融合基因及其信号转导通路在恶性肿瘤包括肝细胞肝癌、胰腺癌、非小细胞肺癌等发生发展中的作用；
细胞蛋白质稳态的调节及在恶性肿瘤发生发展中的作用;
肿瘤免疫微环境，慢性炎症在肿瘤发生发展中的作用。
2021，国家自然科学基金青年项目，“E3泛素连接酶TRIM21在多柔比星心脏毒性的影响及潜在价值研究”，主持
2019，上海市自然科学基金委，“TRIM21对细胞氧化还原平衡的调节及其在肝细胞肝癌中的作用”，主持
2018，美国国立卫生院，“高迁移族蛋白1的翻译后修饰在肝细胞肝癌发生和进展中的作用”，参与
本科生课程：
Medical Genetics（MBBS）、医学遗传学、细胞与医学遗传学实验
研究生课程：
细胞生物学、医学遗传学进展
Gao, S., Li, A-M, Liu, F., Chen, F., Williams, MR., Zhang, C-L, Kelly Z, Wu, CL, Luo R-C, Xiao H. Ncoa5 Haplo-insufficiency Results in Glucose Intolerance and Hepatocellular Carcinoma. Cancer Cell 24 (6), 725–737, 9 December, 2013
Kai Hou, Jianliang Shen, Junrong Yan, Chuannan Zhai, Jingxia Zhang, Ji-An Pan,Ye Zhang, Yaping Jiang, Yongbo Wang, Richard Z. Ling, Hongliang Cong*, Shenglan Gao*, Wei-Xing Zong.* Loss of TRIM21 alleviates cardiotoxicity by suppressing ferroptosis induced by the chemotherapeutic agent doxorubicin. EBioMedicine, 69,103456, 2021
Dipti Athavale, Zhuolun Song, Romain Desert, Hui Han, Sukanta Das, Xiaodong Ge, Sai Santosh Babu Komakula, Wei Chen, Shenglan Gao, Daniel Lantvit, Grace Guzman, Natalia Nieto. Ablation of high-mobility group box-1 in the liver reduces hepatocellular carcinoma but causes hyperbilirubinemia in Hippo signaling-deficient mice. Hepatol Commun. doi: 10.1002/hep4.1943. Mar 28, 2022.
Fang Wang#, Ye Zhang#, Jianliang Shen, Bin Yang, Weiwei Dai, Junrong Yan, Sara Maimouni, Heineken Q. Daguplo, Sara Coppola,Yingtang Gao,Yijun Wang, Zhi Du,Kesong Peng, Hui Liu, Qin Zhang, Fei Tang, Peng Wang, Shenglan Gao, Yongbo Wang, Wen-Xing Ding, Grace Guo, Fengmei Wang, and Wei-Xing Zong. The Ubiquitin E3 Ligase TRIM21 Promotes Hepatocarcinogenesis by Suppressing the p62-Keap1-Nrf2 Antioxidant Pathway. Cellular and Molecular Gastroenterology and Hepatology, Volume 11, Issue 5, 2021, Pages 1369-1385, 2021
Shenglan Gao, Yueqi Zhang, Chengfeng Yang, Gloria I. Perez, Hua Xiao* NCOA5 Haplo-insufficiency Results in Male Mouse Infertility through Increased IL-6 Expression in the Epididymis. Scientific Reports, 9:15525, 2019
Liu, X.*, Liu, F.*, Gao, S., Reske J., Li A-M, Wu CL., Yang, C., Luo, R-C, and Xiao, H. A missense NCOA5 variant in type 2 diabetic patients with hepatocellular carcinoma impairs the function of NCOA5 in cell cycle regulation. Cancer Letters 391,152-161, 2017/4/10, 2017
Chen, F, Li. A, Gao, S., Hollern, D., VanSickle EA, Williams MR, Andrechek E., Zhang C-L, Yang C., Luo R., and Xiao, H (2014). Tip30 controls differentiation of murine mammary luminal progenitor to estrogen receptor-positive luminal cell through regulating FoxA1 expression. Cell Death and Disease 5, e1242; doi:10.1038/cddis, 2014
Li, A-M, Zhang, C-L, Gao, S., Luo R-C, Xiao, H. TIP30 loss enhances cytoplasmic and nuclear EGFR signaling and promotes lung adenocarcinogenesis in mice. Oncogene 32 (18), 2273-2281, 25 June 2012
Zhang, C-L, Mori, M., Gao, S., Li, A-M., Hoshino, I., Aupperlee, M.D., Haslam, S. Z., and Xiao, H, (2010). Tip30 Deletion in MMTV-Neu Mice Leads to Enhanced EGFR Signaling and Development of Estrogen Receptor-Positive and Progesterone Receptor-Negative Mammary Tumors. Cancer Research 70:10224-10233,15 December, 2010
Zhang, C-L, Li, A-M, Gao, S., Zhang, X, Xiao, H, (2011). The TIP30 Protein Complex, Arachidonic acid and Coenzyme A are Required for Vesicle Membrane Fusion. PLoS ONE 6 (6): e21233, 2011
