张思

  • 职    称:教授

  • 电    话:021-54237896

  • 电子邮箱:zhangsi@fudan.edu.cn

  • 办公地点:上海市徐汇区东安路131号2号科研楼A4-028

  • 个人主页/课题组网页:

  • 教育经历

  • 工作经历

  • 获得奖项

  • 研究方向

  • 科研项目

  • 课程讲授

  • 学术兼职

  • 代表性论著

  • 代表性专利

  • 1995.09—2000.07  安徽医科大学临床医学专业本科生

  • 2008.09—2012.07  复旦大学生物化学与分子生物学专业博士研究生

  • 2000.07—2008.10  williamhill官网助教

  • 2008.11—2014.10  williamhill官网讲师

  • 2014.11—2020.10  williamhill官网副教授,期间在德克萨斯医学中心访学

  • 2020.11—至今     williamhill官网教授

  • 2014,“Reach the world”award,国际血栓与止血协会ISTH

  • 2002,上海医学科技二等奖,上海市医学会

  • 血小板激活机制和抗血栓药物临床转化

  • 肿瘤早期标志物筛选和治疗靶点临床转化

  • 遗传性疾病发病和治疗靶点临床转化

  • 2021,上海市自然科学基金面上项目,“Baz蛋白调控血小板细胞骨架重构和活化的研究”,主持

  • 2018,国家自然科学基金面上项目,“细胞极性蛋白Pard3在血小板中的表达和功能研究”,主持

  • 2016,国家自然科学基金面上项目,“核受体FXR在无核血小板中的表达和功能”,主持

  • 2012,国家自然科学基金青年项目,“P2Y12 受体激活抗血小板凋亡的机制研究”,主持

本科生课程:

  • 分子生物学原理、正常人体形态与功能学概论、生物化学

研究生课程:

  • 生物化学实验

  • 2021-今 Frontiers in pharmocology 客座副主编

  1. Fuing Chen#, Cheng Ni#, Xiaoxiao Wang#, Ruhong Cheng#, Chaolan Pan#, Yumeng Wang, Jianying Liang, Jia Zhang, Jinke Cheng, Y Eugene Chin, Yi Zhou, Zhen Wang, Yiran Guo, She Chen, Stephanie Htun, Erin F. Mathes, Alejandra G. de Alba Campomanes, Anne M. Slavotinek, Si Zhang(通讯)*, Ming Li1,*and Zhirong Yao*. S1P Defects Cause a New Entity of Cataract, Alopecia, Oral Mucosal Disorder, and Psoriasis-like Syndrome. Embo Molecular Medicine. 2022; e14904. doi: 10.15252/emmm.202114904. IF=12

  2. Wang, Biyun; Zhao, Yannan; Li, Yi; Xu, Yingying; Chen, Yun; Jiang, Qiuyu; Yao, Dingjin; Z hang, Li; Hu, Xichun; Fu, Chaowei*; Zhang, Si(通讯)*; Chen, She* ; A plasma SNORD33 signature predicts pla tinum beneft in metastatic triple-negative breast cancer patients, Molecular Cancer, 2022, 21(1): 22. IF=27

  3. Chen, Yufei; Fu, Wanrong; Zheng, Yunbo; Yang, Jing; Liu, Yangyang; Qi, Zhiyong; Wu, Meili ng; Fan, Zhichao; Yin, Kanhua; Chen, Yunfeng; Gao, Wen; Ding, Zhongren; Dong, Jianzeng; Li, Qi*; Zhang, Si(通讯)*; Hu, Liang* ; Galectin 3 enhances platelet aggregation and thrombosis via Dectin-1 activa tion: a translational study, European Heart Journal, 2022, 00: 1-19. IF=30

  4. Yi Zhou, Liang Hu, Wenqing Tang, Dongping Li, Lijie Ma, Hongchun Liu, Shuncai Zhang, Xiaojie Zhang, Ling Dong, Xizhong Shen, She Chen*, Ruyi Xue* and Si Zhang(通讯)*. Hepatic NOD2 promotes hepatocarcinogenesis via a RIP2-mediated proinflammatory response and a novel nuclear autophagy-mediated DNA damage mechanism. Journal of hematology & oncology. 2021 14(8) 1-19. IF=17

  5. Xinyi Liu, Yanjie Chen, Si Zhang (通讯)*& Ling Dong. Gut microbiota-mediated immunomodulation in tumor. Journal of Experimental & Clinical Cancer Research, 2021, 40(1): 1-20. IF=11

  6. Si Zhang*(通讯), Yangyang Liu, Xiaofang Wang, Li Yang, Haishan Li, Yuyan Wang, Mengduan Liu, Xiaoyan Zhao, Youhua Xie, Yan Yang, Shenghui Zhang, Zhichao Fan, Jianzeng Dong, Zhenghong Yuan, Zhongren Ding, Yi Zhang* & Liang Hu*. SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19. Journal of hematology & oncology, 2020,13(1), 1-22. SCI; IF=17

  7. Pingping Dong,Xiaoxiao Wang,Longzi Liu,Wenqing Tang,Lijie Ma,Wenjiao Zeng,Shaoyang Sun,Li Zhang,Ningping Zhang,Xizhong Shen,Harry L.A. Janssen,Ling Dong*,Si Zhang*(通讯), She Chen* . Dampened VEPH1 activates mTORC1 signaling by weakening the TSC1/TSC2 association in hepatocellular carcinoma. Journal of Hepatology. 2020, 73(6), 1446-1459. IF=20.58

  8. Si Zhang,Shenghui Zhang, Liang Hu, Lili Zhai, Ruyi Xue, Jianqin Ye, Leilei Chen,Guanjun Cheng, Jozef Mruk, SP Kunapuli, Zhongren Ding. Nucleotide-Binding Oligomerization Domain 2 Receptor Is Expressed in Platelets and Enhances Platelet Activation and Thrombosis. Circulation, 2015. 131(13):1160-70. IF=23

  9. Liu, Xijun; Xue, Ruyi; Yang, Caiting; Gu, Jianxin; Chen, She*; Zhang, Si(通讯)* ; Cholestasis-ind uced bile acid elevates estrogen level via farnesoid X receptor-mediated suppression of the estro gen sulfotransferase SULT1E1. Journal of Biological Chemistry, 2018, 293(33): 12759-12769

  10. Cai, Yu; Huang, Guanqun; Ma, Lijie; Dong, Ling; Chen, She; Shen, Xizhong; Zhang, Shuncai; Xue, Ruyi*; Sun, Deqiang*; Zhang, Si (通讯)*; Smurf2, an E3 ubiquitin ligase, interacts with PDE4B and att enuates liver fibrosis through miR-132 mediated CTGF inhibition. Biochimica et Biophysica Acta-Molecular Cell Research, 2018, 1865(2): 297-308

  1. 小核仁核糖核酸SNORD33作为生物标记物用于制备检测试剂盒中的用途 (申请:CN201811173295.7)

  2. 模式识别受体TREM2在肝癌预后和治疗中的应用(申请:CN201810840310.2)

  3. FXR激动剂在制备治疗脂肪肉瘤相关疾病药物中的用途(已授权:ZL201710204000.7)

  4. BF061固体分散体及其制备方法和在制药中的用途(已授权:CN108338974B)

  5. 肿瘤血管破坏剂DMXAA在制备抗血小板、抗血栓药物中的用途(已授权:CN103800317B)