职 称:研究员
电 话:021-54237223
电子邮箱:shechen@fudan.edu.cn
办公地点:上海市徐汇区东安路131号 科研二号楼A4-003
个人主页:/biochemisry
教育经历
工作经历
获得奖项
研究方向
科研项目
课程讲授
学术兼职
代表性论著
代表性专利
1993.09—1998.06 上海医科大学临床医学系学士
1998.09—2003.06 复旦大学上海医学院生物化学与分子生物学专业博士研究生
2003.08—2006.07 美国纽约州立基础研究所,Research Scientist
2006.07—2013.01 美国纽约斯隆凯特琳癌症中心,Research Associate
2013.06—至今 williamhill官网研究员
2019.11—2020.11 上海市崇明区医疗保障局副局长
2018,复旦大学三八红旗手
2006,第十届国际Alzheimer’s Disease 及其相关疾病大会 Fellowship
2003,上海市科学技术进步奖二等奖(第三完成者)
2002,上海市医学科技奖二等奖(第四完成者)
肿瘤发生与微环境
环境与健康
2022,国家自然科学基金面上项目,“CAPS1通过调控磷酸戊糖途径影响肝癌转移的分子机制研究”,主持
2020,国家自然科学基金面上项目,“极性蛋白Par3调控翻译起始参与结直肠癌发生发展的分子机制研究”,主持
2018,国家自然科学基金面上项目,“极性蛋白Par3参与肝癌发生发展的分子机制研究”,主持
2014,国家自然科学基金面上项目,“Dasm1 调控神经树突发育的机制研究”,主持
本科生课程:生物化学
研究生课程:生物大分子,神经发育学
2017.05-今上海细胞生物学会,理事
Wang, B. #, Zhao, Y. #, Li, Y. #, Xu, Y. #, Chen, Y., Jiang, Q., Yao, D., Zhang, L., Hu, X. *, Fu, C. *, Zhang, S. *, and Chen, S. * (2022) A plasma SNORD33 signature predicts platinum benefit in metastatic triple-negative breast cancer patients. Mol Cancer 21, 22
Zhou, Y. #, Hu, L. #, Tang, W., Li, D., Ma, L., Liu, H., Zhang, S., Zhang, X., Dong, L., Shen, X., Chen, S. *, Xue, R. *, and Zhang, S. * (2021) Hepatic NOD2 promotes hepatocarcinogenesis via a RIP2-mediated proinflammatory response and a novel nuclear autophagy-mediated DNA damage mechanism. J Hematol Oncol 14, 9
Wang, X. X. #, Zhang, S. #, Dong, P. P. #, Li, Y. H., Zhang, L., Shi, S. H., Yu, Z. Q. *, and Chen, S. *. (2021) MRCKbeta links Dasm1 to actin rearrangements to promote dendrite development. J Biol Chem 296, 100730
Wang, S. #, Cai, J. #, Zhang, S., Dong, M., Zhang, L., Xu, Y., Shen, B. *, and Chen, S. * (2021) Loss of polarity protein Par3, via transcription factor Snail, promotes bladder cancer metastasis. Cancer Sci 112, 2625-2641
Dong, P. #, Wang, X. #, Liu, L. #, Tang, W., Ma, L., Zeng, W., Sun, S., Zhang, L., Zhang, N., Shen, X., Janssen, H. L. A., Dong, L. *, Zhang, S. *, and Chen, S. * (2020) Dampened VEPH1 activates mTORC1 signaling by weakening the TSC1/TSC2 association in hepatocellular carcinoma. J Hepatol 73, 1446-1459
Zhao, G. X. #, Xu, Y. Y. #, Weng, S. Q. #, Zhang, S., Chen, Y., Shen, X. Z. *, Dong, L. *, and Chen, S. * (2019) CAPS1 promotes colorectal cancer metastasis via Snail mediated epithelial mesenchymal transformation. Oncogene 38, 4574-4589
Liu, W. A., Chen, S., Li, Z., Lee, C. H., Mirzaa, G., Dobyns, W. B., Ross, M. E., Zhang, J., and Shi, S. H. (2018) PARD3 dysfunction in conjunction with dynamic HIPPO signaling drives cortical enlargement with massive heterotopia. Genes Dev 32, 763-780
Chen, S. #*, Chen, J. #, Shi, H., Wei, M., Castaneda-Castellanos, D. R., Bultje, R. S., Pei, X., Kriegstein, A. R., Zhang, M., and Shi, S. H. * (2013) Regulation of microtubule stability and organization by mammalian Par3 in specifying neuronal polarity. Dev Cell 24, 26-40
Brown, K. N., Chen, S., Han, Z., Lu, C. H., Tan, X., Zhang, X. J., Ding, L., Lopez-Cruz, A., Saur, D., Anderson, S. A., Huang, K., and Shi, S. H. * (2011) Clonal production and organization of inhibitory interneurons in the neocortex. Science 334, 480-486
Chen, S., Li, B., Grundke-Iqbal, I., and Iqbal, K. * (2008) I1PP2A affects tau phosphorylation via association with the catalytic subunit of protein phosphatase 2A. J Biol Chem 283, 10513-10521
小核仁核糖核酸SNORD33作为生物标记物用于制备检测试剂盒中的用途 (申请号:2018107033428)