职 称:研究员
电 话:021-54232382
电子邮箱:jinghehuang@fudan.edu.cn
办公地点:上海市徐汇区东安路131号复星楼407
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1995.09—1999.07 暨南大学生物系本科生
1999.09—2002.07 暨南大学生物系研究生
2002.09—2007.01 清华大学生命科学系博士
2007.8—2010.12 麻省总医院,麻省理工学院与哈佛大学的联合研究中心
2010.11—2016.12 美国国立卫生研究院博士后研究员
2017.01—至今 williamhill官网研究员
2018.06—至今 上海公共卫生临床中心双聘研究员
2018,上海卫生系统百人计划,上海市卫健委
2017,“十三五”重大专项“艾滋病功能性治愈策略与临床研究”牵头人
2016,国家高层次人才计划入选者
2021,高等学校科学研究优秀成果奖”自然科学奖二等奖,教育部
2020,抗击新冠肺炎疫情先进个人”称号,复旦大学
2018,优秀奖励计划“杰出贡献奖”,williamhill官网
2015,年优秀工作奖,美国国立卫生研究院
2014,年优秀工作奖,美国国立卫生研究院
抗病毒广谱中和抗体药物的开发和中和机理研究
抗病毒广谱中和抗体的生物治疗应用研究
新发突发传染病防治策略研究
2022.12-2026.12, 国家教育部“长江学者”特岗,重大传染性疾病防治。100万元,主持
2018.7-2021.6,上海市卫生计生系统“百人计划,2018BR08,比较中国与欧美非地区HIV-1广谱中和抗体中和机制的差异。45万元,主持
2018.1-2021.12,国家自然科学基金委员会,面上项目,31771008,针对中国艾滋病病人的特异性治疗抗体的开发及作用机理的研究。60万元,主持
2017.1-2021.6,十三五国家科技重大专项,2017ZX10202102,艾滋病功能性治愈策略与临床研究。10184.55万元,课题总负责人
2017.1-2020.12,国家计划, 500万元,主持
科生课程:艾滋病临床与基础(英文)
研究生课程:新发与再现传染病的研究前沿与展望
2020-今中国性病艾滋病防治协会青年专业委员会常务委员
2020-今中国性病艾滋病防治协会艾滋病基础研究专业委员会委员
2020-至今 山西省人民政府和疾病控制预防中心特聘专家
2018-至今 国家自然科学基金函审评委
2018-2019全国艾滋病大挑战会议执行主席
Yingdan Wang#, Meiqin Liu#, Yaping Shen#, Yunping Ma#, Xiang Li#, Yuanyuan Zhang#, Xing-Lou Yang#, Mei Liu#, Jun Chen#, Renhong Yan, Die Luan, Yanqun Wang, Ying Chen, Qimin Wang, Haofeng Lin, Yaning Li, Kaiyue Wu, Tongyu Zhu, Jincun Zhao, Hongzhou Lu*, Yumei Wen*, Shibo Jiang*, Fan Wu*, Qiang Zhou*, Zheng-Li Shi*, Jinghe Huang*. Novel sarbecovirus bispecific neutralizing antibodies with exceptional breadth and potency against currently circulating SARS-CoV-2 variants and sarbecoviruses. Cell Discovery. 2022 (Accepted)
Yingdan Wang#, Yunping Ma#, Yan Xu#, Jiangyan Liu#, Xiang Li, Yuyuan Chen, Yan Chen, Jun Xie, Lianbo Xiao, Zheng Xiang*, Fan Wu*, Jinghe Huang*. Resistance of SARS-CoV-2 Omicron Variant to Convalescent and CoronaVac Vaccine Plasma. EMI 2022 (1):424-427
Xiren Deng, Qimin Wang, Mei Liu, Qinwen Zheng, Fan Wu* and Jinghe Huang* Tetrameric NA of Influenza A virus is required to induce protective antibody responses in mice. Frontiers in Microbiology. 2021 12:729914.
Fan Wu*, Mei Liu, Aojie Wang, Lu Lu, Qimin Wang, Chenjian Gu, Jun Chen, Yang Wu, Shuai Xia, Yun Ling, Yuling, Zhang, Jingna Xun, Rong Zhang, Youhua Xie, Shibo Jiang, Tongyu Zhu, Hongzhou Lu, Yumei Wen, Jinghe Huang*. Evaluating the Association of Clinical Characteristics With Neutralizing Antibody Levels in Patients Who Have Recovered From Mild COVID-19 in Shanghai, China. JAMA Internal Medicine. 2020 180(10):1356-1362.
Qimin Wang#, Yuling Zhang#, Peng Zou, Meixiang Wang, Weihui Fu, Jialei She, Zhigang Song, Jianqing Xu, Jinghe Huang*, Fan Wu*. Self-assembly M2e-based peptide nanovaccine confers cross-protection against influenza viruses. Front. Microbiol. 2020; 11: 1961. doi: 10.3389/fmicb.2020.01961.
Matsuda K#, Huang J#, Zhou T, Sheng Z, Kang BH, Ishida E, Griesman T, Stuccio S, Bolkhovitinov L, Wohlbold TJ, Chromikova V, Cagigi A, Leung K, Andrews S, Cheung CSF, Pullano AA, Plyler J, Soto C, Zhang B, Yang Y, Joyce MG, Tsybovsky Y, Wheatley A, Narpala SR, Guo Y, Darko S, Bailer RT, Poole A, Liang CJ, Smith J, Alexander J, Gurwith M, Migueles SA, Koup RA, Golding H, Khurana S, McDermott AB, Shapiro L, Krammer F, Kwong PD, Connors M. Prolonged evolution of the memory B cell response induced by a replicating adenovirus-influenza H5 vaccine. Sci. Immunol. 2019; 4(34). eaau2710 doi: 10.1126/sciimmunol.aau2710.
Huang J#, Kang BH#, Ishida E#, Zhou T#, Griesman T, Sheng Z, Wu F, Doria-Rose NA, Zhang B, McKee K, O'Dell S, Chuang GY, Druz A, Georgiev IS, Schramm CA, Zheng A, Joyce MG, Asokan M, Ransier A, Darko S, Migueles SA, Bailer RT, Louder MK, Alam SM, Parks R, Kelsoe G, Von Holle T, Haynes BF, Douek DC, Hirsch V, Seaman MS, Shapiro L, Mascola JR, Kwong PD, Connors M*. Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth. Immunity. 2016, 45(5):1108-1121
Huang J, Kang B, Pancera M, Lee JH, Tong T, Feng Y, Imamichi H, Georgiev I, Chuang GY, Druz A, Doria-Rose NA, Laub L, Sliepen K, van Gils M, de la Peña AT, Derking R, Klasse PJ, Migueles SA, Bailer RT, Alam SM, Pugach P, Haynes BF, Wyatt RT, Sanders RW, Binley JM, Ward AB, Mascola JR, KwongPD, Connors M*. Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-120 interface Nature. 2014, 515(7525):138-42
Huang J#, Doria-Rose NA#, Longo NS#, Laub L, Lin CL, Turk E, Kang B, Migueles SA, Bailer RT, Mascola JR, Connors M*. Isolation of human monoclonal antibodies from peripheral blood B cells. Nature Protocols. 2013, 8(10):1907-1915
Huang J#, Ofek G#, Laub L, Louder MK, Doria-Rose NA, Longo NS, Imamichi H, Bailer RT, Chakrabarti B, Sharma SK, Alam SM, Wang T, Yang Y, Zhang B, Migueles SA, Wyratt R, Haynes BF, KwongPD, Mascola JR, Connors M*. Broad and potent neutralization of HIV-1 by a gp41-specific human antibody. Nature. 2012, 491(7424):406-12
黄竞荷,吴凡,王应丹。一种中和冠状病毒的双特异性抗体 申请号:202111563268.2 专利申请日:2021.12.20
黄竞荷,吴凡,王应丹。一种结合冠状病毒的双特异性抗体 申请号:2021107479840 专利申请日:2021.04.30
黄竞荷,吴凡,刘梅。一种特异性结合冠状病毒的抗体或其抗原结合片段 已授权ZL202010740319.3
Mark Connors, Jinghe Huang, Byong Kang, John Mascola, Elise Ishida, Tongqing Zhou, Peter Kwong, Anqi Zheng. Neutralizing antibodies to HIV-1 gp120 and their use. Publication date: 2016/9/29 美国 Patent number:WO2016154003A8
2015 Mark Connors, Jinghe Huang, Byong Kang, Peter Kwong, John Mascola, Marie Pancera, Andrew Ward, Tongqing Zhou. Neutralizing antibodies to HIV-1 env and their use. Publication date: 2015/7/9 美国Patent number: WO2015103549A1