李蓓

  • 职    称:青年副研究员

  • 联系电话:021-54237105

  • 电子邮箱:beili@fudan.edu.cn

  • 办公地点:上海市徐汇区东安路130号西13号楼707室

  • 个人主页/课题组网页:

  • 教育经历

  • 工作经历

  • 研究方向

  • 科研项目

  • 代表性论著

  • 2011.04 — 2017.02瑞士苏黎世大学,分子生物学系,博士

  • 2005.09 — 2008.03同济大学,生物化学与分子生物学系,硕士

  • 2001.09 — 2005.06扬州大学,生物技术系,本科

  • 2022.02 — 至今williamhill官网,中西医结合学系,青年副研究员

  • 2019.10 — 2022.01williamhill官网,神经生物学系,博士后

  • 2010.01 — 2011.03瑞士苏黎世大学医院,神经病理学研究所,研究助理

  • 神经退行性疾病的发病机制和诊治方法

  • 全自动高通量筛选在疾病研究和药物开发中的应用

  • 2022,国家自然科学基金青年基金项目,国家自然科学基金委员会,主持

  • 2021,中国博士后科学基金面上项目资助一等,中国博士后科学基金会,主持

  1. Bei Li, Meiling Chen, Adriano Aguzzi, Caihong Zhu. The role of macrophage scavenger receptor 1 (Msr1) in prion pathogenesis. Journal of Molecular Medicine (Berlin, Germany). 2021; 99(6), 877–887.

  2. Bei Li#, Meiling Chen#, Caihong Zhu.Neuroinflammation in Prion Disease. International Journal of Molecular Sciences. 2021;22(4), 2196.

  3. Caihong Zhu#, Bei Li#, Karl Frontzek, Yingjun Liu, Adriano Aguzzi. SARM1 deficiency up-regulates XAF1, promotes neuronal apoptosis, and accelerates prion disease. The Journal of Experimental Medicine. 2019; 216(4), 743–756.

  4. Marian Hruska-Plochan#, Bei Li#, Diego Kyburz, Jan Krützfeld, Ulf Landmesser, Adriano Aguzzi, Magdalini Polymenidou. New and emerging roles of small RNAs in neurodegeneration, muscle, cardiovascular and inflammatory diseases. Swiss Medical Weekly. 2015;145, w14192.

  5. Caihong Zhu, Zhihao Li, Bei Li, Manuela Pfammatter, Simone Hornemann, Adriano Aguzzi. Unaltered prion disease in mice lacking developmental endothelial locus-1. Neurobiology of Aging. 2019; 76, 208–213.

  6. Uli S Herrmann, Anne K Schütz, Hamid Shirani, Danzhi Huang, Dino Saban, Mario Nuvolone, Bei Li, Boris Ballmer, Andreas K O Åslund, Jeffrey J Mason, Elisabeth Rushing, Herbert Budka, Sofie Nyström, Per Hammarström, Anja Böckmann, Amedeo Caflisch, Beat H Meier, K Peter R Nilsson, Simone Hornemann, Adriano Aguzzi. Structure-based drug design identifies polythiophenes as antiprion compounds. Science Translational Medicine. 2015; 7(299), 299ra123.

  7. Caihong Zhu, Uli S Herrmann, Bei Li, Irina Abakumova, Rita Moos, Petra Schwarz, Elisabeth J Rushing, Marco Colonna, Adriano Aguzzi. Triggering receptor expressed on myeloid cells-2 is involved in prion-induced microglial activation but does not contribute to prion pathogenesis in mouse brains. Neurobiology of Aging. 2015; 36(5), 1994–2003.

  8. Uli S Herrmann, Tiziana Sonati, Jeppe Falsig, Regina R Reimann, Paolo Dametto, Tracy O'Connor, Bei Li, Agnes Lau, Simone Hornemann, Silvia Sorce, Uli Wagner, Despina Sanoudou, Adriano Aguzzi. Prion infections and anti-PrP antibodies trigger converging neurotoxic pathways. PLoS Pathogens. 2015; 11(2), e1004662.

  9. Tiziana Sonati, Regina R Reimann, Jeppe Falsig, Pravas Kumar Baral, Tracy O'Connor, Simone Hornemann, Sine Yaganoglu, Bei Li, Uli S Herrmann, Barbara Wieland, Mridula Swayampakula, Muhammad Hafizur Rahman, Dipankar Das, Nat Kav, Roland Riek, Pawel P Liberski, Michael N G James, Adriano Aguzzi. The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein. Nature. 2013; 501(7465), 102–106.

  10. Jeppe Falsig, Tiziana Sonati, Uli S Herrmann, Dino Saban, Bei Li, Karina Arroyo, Boris Ballmer, Pawel P Liberski, Adriano Aguzzi. Prion pathogenesis is faithfully reproduced in cerebellar organotypic slice cultures. PLoS Pathogens. 2012; 8(11), e1002985.